{"id":3448,"date":"2026-02-09T15:50:41","date_gmt":"2026-02-09T14:50:41","guid":{"rendered":"https:\/\/5senses4kids.org\/en\/?p=3448"},"modified":"2026-03-09T16:00:49","modified_gmt":"2026-03-09T15:00:49","slug":"interview-with-gwenola-le-drean-part-1","status":"publish","type":"post","link":"https:\/\/5senses4kids.org\/en\/interview-with-gwenola-le-drean-part-1\/","title":{"rendered":"Interview with Gwenola Le Dr\u00e9an \u2013 Part 1"},"content":{"rendered":"\n<div class=\"wp-block-group container\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading container has-text-color\" id=\"qu-est-ce-que-l-apprentissage-multisensoriel\" style=\"color:#3c7a95;font-size:50px\">Interview with Gwenola Le Dr\u00e9an \u2013 Part 1<\/h1>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><div class=\"wpcp-wp-lightbox-host wpcp-advanced-image-lightbox-icon-hover\"><a class=\"wpcp-wp-lightbox-image-link\" href=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Photo-Gwenola-Le-Drean.jpg\" data-wpcp-wp-lb-image=\"1\"><img decoding=\"async\" src=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Photo-Gwenola-Le-Drean.jpg\" alt=\"\" class=\"wp-image-9069\" style=\"aspect-ratio:0.8933277774884109;width:386px;height:auto\" \/><\/a><a href=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Photo-Gwenola-Le-Drean.jpg\" data-fancybox=\"wpcp-wp-img-9069\" class=\"wpcp-lightbox-trigger wpcp-advanced-image-lightbox-icon wpcp-position-top-right wpcp-advanced-image-lightbox-icon-hover wpcp-global-lightbox-icon wpcp-lightbox-icon--global wpcp-lb-icon-style-default\" data-wpcp-lb-icon-source=\"global\" aria-label=\"Open image in lightbox\" data-thumb-src=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Photo-Gwenola-Le-Drean.jpg\" data-wpcp-lb-single=\"1\"><span class=\"wpcp-icon-container\"><svg viewBox=\"0 0 20 20\"><path d=\"M17.6585 16.025L14.2437 12.6198C15.1716 11.3338 15.6121 9.7613 15.4871 8.1819C15.362 6.60251 14.6795 5.11847 13.5607 3.99351C12.936 3.36206 12.1916 2.86066 11.3709 2.51845C10.5502 2.17623 9.66952 2 8.77995 2C7.89039 2 7.00969 2.17623 6.18899 2.51845C5.36829 2.86066 4.62395 3.36206 3.99919 3.99351C3.36594 4.61649 2.86312 5.35871 2.51992 6.17708C2.17673 6.99545 2 7.87365 2 8.76068C2 9.64772 2.17673 10.5259 2.51992 11.3443C2.86312 12.1627 3.36594 12.9049 3.99919 13.5279C5.11957 14.6901 6.62279 15.4103 8.23285 15.5562C9.84291 15.7022 11.4517 15.2641 12.7639 14.3224L16.1788 17.7275C16.3849 17.9034 16.6473 18 16.9186 18C17.1899 18 17.4523 17.9034 17.6585 17.7275C18.1138 17.16 18.1138 16.5925 17.6585 16.025ZM5.59278 12.0523C5.16258 11.6298 4.82094 11.1263 4.58774 10.5709C4.35455 10.0156 4.23446 9.41951 4.23446 8.81744C4.23446 8.21536 4.35455 7.6193 4.58774 7.06394C4.82094 6.50859 5.16258 6.00503 5.59278 5.58257C6.01644 5.15359 6.52144 4.81292 7.07838 4.58039C7.63532 4.34786 8.23308 4.22811 8.83687 4.22811C9.44066 4.22811 10.0384 4.34786 10.5954 4.58039C11.1523 4.81292 11.6573 5.15359 12.081 5.58257C12.5112 6.00503 12.8528 6.50859 13.086 7.06394C13.3192 7.6193 13.4393 8.21536 13.4393 8.81744C13.4393 9.41951 13.3192 10.0156 13.086 10.5709C12.8528 11.1263 12.5112 11.6298 12.081 12.0523C11.6573 12.4813 11.1523 12.822 10.5954 13.0545C10.0384 13.287 9.44066 13.4068 8.83687 13.4068C8.23308 13.4068 7.63532 13.287 7.07838 13.0545C6.52144 12.822 6.01644 12.4813 5.59278 12.0523Z\" \/><\/svg><\/span><\/a><\/div><\/figure>\n<\/div>\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group grid-sensorielle container\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-4ab747a0f379e7ee3841d0c61eb5f070 wp-block-paragraph\" style=\"color:#3c7a95\"><strong>Today we have the pleasure of interviewing Gwenola Le Dr\u00e9an<\/strong>, physiologist and specialist in the gut-brain axis, who is a researcher at INRAE (the French National Research Institute for Agriculture, Food and the Environment) at the UMR 1280 &#8220;Physiopathology of Nutritional Adaptations&#8221; laboratory, which she co-directs in Nantes.<\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-52ef9a44b0d2f4e81fa76c4634d982eb wp-block-paragraph\" style=\"color:#3c7a95\">Your research aims to understand how unbalanced perinatal nutrition increases the risk of metabolic and cognitive diseases later in life. Among other things, you are studying the communication between hormone-producing intestinal cells and sensory neurons that signal the presence of nutrients and bacterial metabolites in the intestinal lumen to the brain.<\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-c6abd119e007f5b7ac03e84ec688425d wp-block-paragraph\" style=\"color:#3c7a95\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-color\" style=\"color:#3c7a95;font-size:26px\"><strong><strong>First of all, can you tell us about the concept of the developmental origins of health and disease?<\/strong> <\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-3894b3b93049fec7de75e67bf9fc283b wp-block-paragraph\" style=\"color:#3c7a95\"><strong>The concept of the developmental origins of health and disease<\/strong>, known by the acronym DOHaD, was first proposed in the 1990s by an English doctor, D.J. Barker. He highlighted that an altered nutritional environment during the prenatal period predisposes individuals to cardio-metabolic diseases later in life, such as type 2 diabetes, hypertension and obesity. Barker&#8217;s epidemiological studies are based on monitoring individuals whose birth weight and weight at one year of age were recorded in the Hertfordshire cohort, as well as those who were exposed to famine <em>in utero<\/em> during the &#8220;Dutch Hunger Winter&#8221; in 1944. These studies led him to conclude that the metabolism and growth of a foetus in a situation of nutritional deficiency adapts to this impoverished environment. This metabolic adaptation induces a &#8220;thrifty phenotype&#8221; that protects the development of key organs such as the brain and kidneys, at the expense of growth.<\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-fd4ba3dd46c47a90a5ee96ca1c4e3483 wp-block-paragraph\" style=\"color:#3c7a95\">However, when faced with the abundance of calories frequently found in Western diets high in fat and sugar, this phenotype is not always able to adapt and contributes to the development of chronic metabolic diseases, such as cardiovascular, metabolic and cognitive disorders later in life. <\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-69710387558fe6dedb1c0e65a3aa5572 wp-block-paragraph\" style=\"color:#3c7a95\">Interestingly, it has since been shown that an unbalanced perinatal nutritional environment \u2013 whether it is deficient or excessive in calories or essential nutrients \u2013 creates a similar possibility of developing these diseases, due to the high plasticity of developing organs.<\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-aeaa6a46524a9e1a402b1b9ff617605d wp-block-paragraph\" style=\"color:#3c7a95\">While this perinatal window of the first 1,000 days, from conception to the first two years of life, is extremely sensitive to the environment, it also provides an opportunity for prevention and intervention to correct or limit the risk of future diseases.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><div class=\"wpcp-wp-lightbox-host wpcp-advanced-image-lightbox-icon-hover\"><a class=\"wpcp-wp-lightbox-image-link\" href=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Image-1-article-impact-nutrition-1024x550.jpg\" data-wpcp-wp-lb-image=\"1\"><img decoding=\"async\" src=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Image-1-article-impact-nutrition-1024x550.jpg\" alt=\"\" class=\"wp-image-9076\" style=\"aspect-ratio:1.8618826626030338\" \/><\/a><a href=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Image-1-article-impact-nutrition-1024x550.jpg\" data-fancybox=\"wpcp-wp-img-9076\" class=\"wpcp-lightbox-trigger wpcp-advanced-image-lightbox-icon wpcp-position-top-right wpcp-advanced-image-lightbox-icon-hover wpcp-global-lightbox-icon wpcp-lightbox-icon--global wpcp-lb-icon-style-default\" data-wpcp-lb-icon-source=\"global\" aria-label=\"Open image in lightbox\" data-thumb-src=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Image-1-article-impact-nutrition-1024x550.jpg\" data-wpcp-lb-single=\"1\"><span class=\"wpcp-icon-container\"><svg viewBox=\"0 0 20 20\"><path d=\"M17.6585 16.025L14.2437 12.6198C15.1716 11.3338 15.6121 9.7613 15.4871 8.1819C15.362 6.60251 14.6795 5.11847 13.5607 3.99351C12.936 3.36206 12.1916 2.86066 11.3709 2.51845C10.5502 2.17623 9.66952 2 8.77995 2C7.89039 2 7.00969 2.17623 6.18899 2.51845C5.36829 2.86066 4.62395 3.36206 3.99919 3.99351C3.36594 4.61649 2.86312 5.35871 2.51992 6.17708C2.17673 6.99545 2 7.87365 2 8.76068C2 9.64772 2.17673 10.5259 2.51992 11.3443C2.86312 12.1627 3.36594 12.9049 3.99919 13.5279C5.11957 14.6901 6.62279 15.4103 8.23285 15.5562C9.84291 15.7022 11.4517 15.2641 12.7639 14.3224L16.1788 17.7275C16.3849 17.9034 16.6473 18 16.9186 18C17.1899 18 17.4523 17.9034 17.6585 17.7275C18.1138 17.16 18.1138 16.5925 17.6585 16.025ZM5.59278 12.0523C5.16258 11.6298 4.82094 11.1263 4.58774 10.5709C4.35455 10.0156 4.23446 9.41951 4.23446 8.81744C4.23446 8.21536 4.35455 7.6193 4.58774 7.06394C4.82094 6.50859 5.16258 6.00503 5.59278 5.58257C6.01644 5.15359 6.52144 4.81292 7.07838 4.58039C7.63532 4.34786 8.23308 4.22811 8.83687 4.22811C9.44066 4.22811 10.0384 4.34786 10.5954 4.58039C11.1523 4.81292 11.6573 5.15359 12.081 5.58257C12.5112 6.00503 12.8528 6.50859 13.086 7.06394C13.3192 7.6193 13.4393 8.21536 13.4393 8.81744C13.4393 9.41951 13.3192 10.0156 13.086 10.5709C12.8528 11.1263 12.5112 11.6298 12.081 12.0523C11.6573 12.4813 11.1523 12.822 10.5954 13.0545C10.0384 13.287 9.44066 13.4068 8.83687 13.4068C8.23308 13.4068 7.63532 13.287 7.07838 13.0545C6.52144 12.822 6.01644 12.4813 5.59278 12.0523Z\" \/><\/svg><\/span><\/a><\/div><\/figure>\n\n\n\n<p class=\"has-text-color has-link-color has-small-font-size wp-elements-b3238e9b47b776bc66d3b1c09f0b3386 wp-block-paragraph\" style=\"color:#3c7a95\"><em>The concept of DOHaD illustrated by the consequences of perinatal malnutrition on the risk of chronic diseases later in life. Created by BioRender and adapted from Mayneris-Perxachs and Swann, 2019.<\/em><\/p>\n\n\n\n<div style=\"height:42px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-color wp-block-paragraph\" style=\"color:#3c7a95;font-size:26px\"><strong><strong>Thank you. And to better understand these issues, can you explain the role of nutrition in the first 1,000 days on the microbiota-gut-brain axis?<\/strong> <\/strong><\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-80adffc9830cf01cb81dc2320502b52d wp-block-paragraph\" style=\"color:#3c7a95\">It is important to note that the gut-brain axis initially defines the bidirectional communication that takes place between these two organs. This communication has been known and described for several decades in the regulation of food intake. When food arrives, the gut sends nutritional and digestive signals \u2013 such as distension of the stomach and small intestine, production of hormones that regulate food intake, etc. to the brain stem, which sends back signals regulating digestive functions such as the motility of the intestinal wall muscles, which ensure the transit of food. All this communication is carried out <em>via<\/em> the bloodstream but also <em>via<\/em> the vagus nerve, which integrates mechanical and hormonal signals as well as those from the nervous and immune systems of the digestive tract. Thus, beyond the establishment of satiety or the state of not being hungry, regulated reflexively through this communication, the signals transmitted by the gut-brain axis play a central role. This role is decisive not only in regulating the energy balance between calorie intake and expenditure, but also in higher cognitive functions such as learning, memory, and the perception of visceral pain, stress and anxiety.<\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-c6abd119e007f5b7ac03e84ec688425d wp-block-paragraph\" style=\"color:#3c7a95\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><div class=\"wpcp-wp-lightbox-host wpcp-advanced-image-lightbox-icon-hover\"><a class=\"wpcp-wp-lightbox-image-link\" href=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Image-2-nutrition-1024x608.jpg\" data-wpcp-wp-lb-image=\"1\"><img decoding=\"async\" src=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Image-2-nutrition-1024x608.jpg\" alt=\"\" class=\"wp-image-9084\" style=\"width:740px;height:auto\" \/><\/a><a href=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Image-2-nutrition-1024x608.jpg\" data-fancybox=\"wpcp-wp-img-9084\" class=\"wpcp-lightbox-trigger wpcp-advanced-image-lightbox-icon wpcp-position-top-right wpcp-advanced-image-lightbox-icon-hover wpcp-global-lightbox-icon wpcp-lightbox-icon--global wpcp-lb-icon-style-default\" data-wpcp-lb-icon-source=\"global\" aria-label=\"Open image in lightbox\" data-thumb-src=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/Image-2-nutrition-1024x608.jpg\" data-wpcp-lb-single=\"1\"><span class=\"wpcp-icon-container\"><svg viewBox=\"0 0 20 20\"><path d=\"M17.6585 16.025L14.2437 12.6198C15.1716 11.3338 15.6121 9.7613 15.4871 8.1819C15.362 6.60251 14.6795 5.11847 13.5607 3.99351C12.936 3.36206 12.1916 2.86066 11.3709 2.51845C10.5502 2.17623 9.66952 2 8.77995 2C7.89039 2 7.00969 2.17623 6.18899 2.51845C5.36829 2.86066 4.62395 3.36206 3.99919 3.99351C3.36594 4.61649 2.86312 5.35871 2.51992 6.17708C2.17673 6.99545 2 7.87365 2 8.76068C2 9.64772 2.17673 10.5259 2.51992 11.3443C2.86312 12.1627 3.36594 12.9049 3.99919 13.5279C5.11957 14.6901 6.62279 15.4103 8.23285 15.5562C9.84291 15.7022 11.4517 15.2641 12.7639 14.3224L16.1788 17.7275C16.3849 17.9034 16.6473 18 16.9186 18C17.1899 18 17.4523 17.9034 17.6585 17.7275C18.1138 17.16 18.1138 16.5925 17.6585 16.025ZM5.59278 12.0523C5.16258 11.6298 4.82094 11.1263 4.58774 10.5709C4.35455 10.0156 4.23446 9.41951 4.23446 8.81744C4.23446 8.21536 4.35455 7.6193 4.58774 7.06394C4.82094 6.50859 5.16258 6.00503 5.59278 5.58257C6.01644 5.15359 6.52144 4.81292 7.07838 4.58039C7.63532 4.34786 8.23308 4.22811 8.83687 4.22811C9.44066 4.22811 10.0384 4.34786 10.5954 4.58039C11.1523 4.81292 11.6573 5.15359 12.081 5.58257C12.5112 6.00503 12.8528 6.50859 13.086 7.06394C13.3192 7.6193 13.4393 8.21536 13.4393 8.81744C13.4393 9.41951 13.3192 10.0156 13.086 10.5709C12.8528 11.1263 12.5112 11.6298 12.081 12.0523C11.6573 12.4813 11.1523 12.822 10.5954 13.0545C10.0384 13.287 9.44066 13.4068 8.83687 13.4068C8.23308 13.4068 7.63532 13.287 7.07838 13.0545C6.52144 12.822 6.01644 12.4813 5.59278 12.0523Z\" \/><\/svg><\/span><\/a><\/div><\/figure>\n<\/div>\n\n\n<p class=\"has-text-color has-link-color has-small-font-size wp-elements-79527fe2b6568ff07816081e30a6726e wp-block-paragraph\" style=\"color:#3c7a95\"><em><em>What role does nutrition during the first 1,000 days play in the microbiota-gut-brain axis and its involvement in certain future health disorders? Created by BioRender.<\/em><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-color\" style=\"color:#3c7a95;font-size:26px\"><strong><strong><strong>Can you also explain what the microbiota does?<\/strong> <\/strong><\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-88d36cbf218c6a92dc338e1aff39ae01 wp-block-paragraph\" style=\"color:#3c7a95\">More recently, a new player has entered the picture in our understanding of this axis: the microbiota and its 10 trillion organisms, which are mainly, but not exclusively, bacteria. The term &#8220;commensal flora&#8221; was sometimes used to define these microorganisms with which we share our nutrients. This microbial ecosystem is now called the &#8220;microbiome&#8221; by specialists in the field, but the term microbiota remains very common.  <\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-32cdcad79008eea37c55be27e8bb3448 wp-block-paragraph\" style=\"color:#3c7a95\">We host our microbiota in a living space that is conducive to its growth, the gut, and we feed it. In return, the microbiota uses a number of molecules that our digestive tract cannot assimilate, produces molecules that are important for our body, such as vitamins, and contributes to the development of the intestines and the immune system. It also helps prevent infections by producing antimicrobial agents while occupying the space that certain pathogenic microorganisms could take up in our intestines. Finally, the gut microbiota also sends messages to our brain by producing molecules such as hormones that regulate appetite and neurotransmitters that ensure communication between neurons. <\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-beda29da567684d87c0419421308d835 wp-block-paragraph\" style=\"color:#3c7a95\">Animal models raised in sterile conditions \u2013 i.e. without microbiota \u2013 or treated with antibiotics remain essential for understanding the role of microbiota in the development of the immune system, the brain and behaviour. It should also be noted that dysfunction of the microbiota-gut-brain axis is often reported in the pathophysiology of many diseases, including mental illness, neurodegenerative diseases, obesity and inflammatory bowel disease.  <\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-f4fd15e84894d28e755b477acfbaf740 wp-block-paragraph\" style=\"color:#3c7a95\">This axis therefore represents a prime target for developing new therapeutic approaches! Of course, experimental research must nevertheless be transposable to humans. This is why translational research aimed at demonstrating the causal role of the microbiota in these disorders is currently underway.<\/p>\n\n\n\n<div style=\"height:38px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><div class=\"wpcp-wp-lightbox-host wpcp-advanced-image-lightbox-icon-hover\"><a class=\"wpcp-wp-lightbox-image-link\" href=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/canva-MAFHCzxhVCs-4.jpg\" data-wpcp-wp-lb-image=\"1\"><img decoding=\"async\" src=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/canva-MAFHCzxhVCs-4.jpg\" alt=\"\" class=\"wp-image-9148\" style=\"aspect-ratio:1.3317695130717717;width:835px;height:auto\" \/><\/a><a href=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/canva-MAFHCzxhVCs-4.jpg\" data-fancybox=\"wpcp-wp-img-9148\" class=\"wpcp-lightbox-trigger wpcp-advanced-image-lightbox-icon wpcp-position-top-right wpcp-advanced-image-lightbox-icon-hover wpcp-global-lightbox-icon wpcp-lightbox-icon--global wpcp-lb-icon-style-default\" data-wpcp-lb-icon-source=\"global\" aria-label=\"Open image in lightbox\" data-thumb-src=\"https:\/\/5senses4kids.org\/wp-content\/uploads\/2026\/01\/canva-MAFHCzxhVCs-4.jpg\" data-wpcp-lb-single=\"1\"><span class=\"wpcp-icon-container\"><svg viewBox=\"0 0 20 20\"><path d=\"M17.6585 16.025L14.2437 12.6198C15.1716 11.3338 15.6121 9.7613 15.4871 8.1819C15.362 6.60251 14.6795 5.11847 13.5607 3.99351C12.936 3.36206 12.1916 2.86066 11.3709 2.51845C10.5502 2.17623 9.66952 2 8.77995 2C7.89039 2 7.00969 2.17623 6.18899 2.51845C5.36829 2.86066 4.62395 3.36206 3.99919 3.99351C3.36594 4.61649 2.86312 5.35871 2.51992 6.17708C2.17673 6.99545 2 7.87365 2 8.76068C2 9.64772 2.17673 10.5259 2.51992 11.3443C2.86312 12.1627 3.36594 12.9049 3.99919 13.5279C5.11957 14.6901 6.62279 15.4103 8.23285 15.5562C9.84291 15.7022 11.4517 15.2641 12.7639 14.3224L16.1788 17.7275C16.3849 17.9034 16.6473 18 16.9186 18C17.1899 18 17.4523 17.9034 17.6585 17.7275C18.1138 17.16 18.1138 16.5925 17.6585 16.025ZM5.59278 12.0523C5.16258 11.6298 4.82094 11.1263 4.58774 10.5709C4.35455 10.0156 4.23446 9.41951 4.23446 8.81744C4.23446 8.21536 4.35455 7.6193 4.58774 7.06394C4.82094 6.50859 5.16258 6.00503 5.59278 5.58257C6.01644 5.15359 6.52144 4.81292 7.07838 4.58039C7.63532 4.34786 8.23308 4.22811 8.83687 4.22811C9.44066 4.22811 10.0384 4.34786 10.5954 4.58039C11.1523 4.81292 11.6573 5.15359 12.081 5.58257C12.5112 6.00503 12.8528 6.50859 13.086 7.06394C13.3192 7.6193 13.4393 8.21536 13.4393 8.81744C13.4393 9.41951 13.3192 10.0156 13.086 10.5709C12.8528 11.1263 12.5112 11.6298 12.081 12.0523C11.6573 12.4813 11.1523 12.822 10.5954 13.0545C10.0384 13.287 9.44066 13.4068 8.83687 13.4068C8.23308 13.4068 7.63532 13.287 7.07838 13.0545C6.52144 12.822 6.01644 12.4813 5.59278 12.0523Z\" \/><\/svg><\/span><\/a><\/div><\/figure>\n\n\n\n<p class=\"has-text-color wp-block-paragraph\" style=\"color:#3c7a95;font-size:26px\"><strong><strong><strong><strong>And why are the first 1,000 days so crucial to the function of the microbiota?<\/strong> <\/strong><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-f14243c9f04fe44ebdc42c891fc7e4ab wp-block-paragraph\" style=\"color:#3c7a95\"><strong>The first 1,000 days are <\/strong>truly critical windows of development. It is during these first 1,000 days that the gut microbiome, and the metabolites it produces, interact with the infant&#8217;s immune system and central nervous system. Bacterial metabolites produced by the maternal microbiota can affect neurodevelopment during the foetal period via the placenta, as is the case with nutrients. However, the baby&#8217;s neurodevelopment continues in the postnatal period as the microbiota colonises the digestive tract. Newborns are born sterile. At the moment of delivery, it encounters its mother&#8217;s vaginal and faecal microbiota if it is born vaginally, or, if it is born by caesarean section, the skin microbiota and that of the delivery room! This neonatal microbiota then settles like a pioneer on virgin territory, proliferating and colonising the digestive tract. This colonisation becomes more complex depending on the child&#8217;s diet and environment until the age of 2, reaching a relatively stable composition \u2013 although still debated \u2013 around the age of 4-6. <\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-3c399bbc0a3fb562376fe129bce601ac wp-block-paragraph\" style=\"color:#3c7a95\">We know that diet is a major factor in the variation of microbiota composition in adults. It is therefore entirely conceivable that a maternal microbiota modified by an unbalanced diet, transmitted at the time of birth, could affect the future health of the baby. In a rodent model, we were able to demonstrate in the laboratory that inocula prepared from the microbiota of obese or thin mothers, distributed to their young at birth and in the days that followed, had different effects on their eating behaviour throughout their lives. These inocula are vaginal, faecal and milk-derived microbiota. It appears that the pups that received microbiota from obese mothers showed changes in their eating behaviour, tending towards hyperphagia. Interestingly, in this model, the composition of the microbiota transmitted at birth did not persist over time. It certainly contributed to the assembly of the final microbiome, but it was not the adult microbiome that explained the differences in eating behaviour observed. Thus, it appears that it was indeed the microbiota received at birth that was responsible for the differences, and we can therefore assume that this neonatal microbiota had an effect on neurodevelopment in early life, with consequences for eating behaviour in adulthood. Other studies of standard microbiota transfer from conventional mice to mice raised without intestinal microbiota \u2013 axenic mice \u2013 have shown that the microbiota received at a young age has a greater effect on exploratory behaviour and stress response than that received in adulthood. <\/p>\n\n\n\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-78d26282c42862508ca19bb69baf04e2 wp-block-paragraph\" style=\"color:#3c7a95\">The postnatal window is therefore a crucial period for the assembly and construction of the baby&#8217;s gut microbiome. The baby will receive its mother&#8217;s microbiota as it has been shaped by maternal nutrition, including her eating habits and behaviours.<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group container\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"has-text-color has-link-color has-medium-font-size wp-elements-62161f30281a02ddc5e5931315dd0a99 wp-block-paragraph\" style=\"color:#3c7a95\">End of the first part of this interview. To access to the 2nd part of this interview, <strong>click here<\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Interview with Gwenola Le Dr\u00e9an &#8211; Part 1. How poor perinatal nutrition increases the risk of metabolic and cognitive disorders later in a child&#8217;s life.<\/p>\n","protected":false},"author":9,"featured_media":3472,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_members_access_role":[],"_members_access_error":""},"categories":[13,14,15],"tags":[],"class_list":["post-3448","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-interviews","category-parents-side","category-scientific-side"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Interview with Gwenola Le Dr\u00e9an - Part 1<\/title>\n<meta name=\"description\" content=\"Thanks to this interview, discover the Olfactory Awakening Manual for young and old, created by the Nez En Herbe association.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/5senses4kids.org\/en\/interview-with-gwenola-le-drean-part-1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Interview with Gwenola Le Dr\u00e9an - 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